Journal of PharmaSciTech Indispensability of Quinoline Moiety in the Field of Medicinal Chemistry Research-A Review

46 Desai et al synthesized a series of new quinoline derivatives and evaluated their pharmacological activity as antimicrobial agents. Quinoline is a heterocyclic aromatic organic compound itrogen atom as part of the ring system, with the chemical formula . It can also be named as, benzopyridine, benzo[b]pyridine, 1benzazine and benzazine. featuring n C H N 9 7 It is a colorless hygroscopic liquid with a strong odor. Aged samples, if exposed to light, become yellow and later brown. Pharmaceutically a wide variety of substituted quinoline derivatives possess a broad range of bioactivities as anticancer, anti malarial, antibiotic, antihypertensive, platelet-derived growth factor receptors tyrosine kinase (PDGF-RTK) inhibition, DNA-intercalating carrier, antiinflammatory and analgesic, anti-HIV, antitumour, DNA binding 1-18 capability, and many other functional material. In the foregoing section, we preferentially wanted to shape our study in a manner to get an efficient knowledge about the target oriented development of quinoline. 2. Quinoline as antimicrobials 2.1. 2, 3-disubstituted quinolines A series of quinoline based imidazole derivatives were synthesized by 25 Desai et al and subsequently evaluated their activity as antimicrobials.